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I love the theatre aaltenpharma.nl Suedhof built on these findings in the 1990s by describing how cells know when to open the packages. Intrigued by how nerve cells communicate with each other in the brain, he searched for proteins that were sensitive to calcium, which was known to be involved in the process. He identified the machinery that was set in motion by an influx of calcium ions, opening the zipper and releasing the contents of the package.